Mar 11, 2022
In this podcast, we are joined by Dr. Kim Thielen, a nephrologist/kidney specialist with Minnesota Kidney Specialists. This episode is part one of a two part series dealing with acute kidney injuries. During this episode Dr. Thielen will discuss pre and post acute kidney injury etiologies. Included with the podcast is additional shownotes that Dr. Thielen references throughout the podcast. Also check out the next podcast/episode on intrinsic kidney injuries.
Enjoy the podcast!
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SHOW
NOTES:
*See the attachment for
additional show information.
Acute Kidney Injury
- Abrupt decrease in kidney
function
- Suspected with oliguria, elevated creatinine, proteinuria, and
hematuria
Oliguria
- Less than 500mls of urine in 24 hour period.
PreRenal
- Anything that decreases circulating volume or
disruption of blood flow to the kidney, causing ischemic kidney
- Causes:
- Total body salt and water depletion
- Dehydration
- Hemorrhage
- Decompensated right or left ventricular failure
- Renal arterial stenosis or renal
vasospasm
Signs and
Symptoms
- Orthostatic, hypotensive, tachycardiac
- Most sensitive indicator of ischemic kidney: Urinary sodium
concentration
Urinary Sodium
Concentration
- Distinguishes between prerenal and instrinsic
causes
- Urine sodium less than 20 in oliguria is indicator of ischemic
kidney
Fractional Excretion of
Sodium
-
Fractional excretion of less than 1% is indicative of ischemic
kidney or a prerenal state
- Fractional excretion of 2% is indicative of tubulules not working
or ATN
Fractional Excretion of
Urea
- For patients on diuretics
- Urea not affected by water concentrating effect of kidney
- Prerenal state: fractional excretion of urea less than 35
- Intrinsic: fractional excretion of urea greater than
35
Classic Presentation of
Prerenal
- BUN to Creatinine Ratio greater than 20.1 signifies
dehydration
- Variables: GI bleed can increase BUN
- Elevated bicarb
Post Renal
Etiologies
- Anything that interfers with the drainage of the urine from the
renal pelvis out to the urethra.
- Causes:
- Intraluminal obstruction: stones or
tumors
- Dysfunctional bladder: spinal injury,
diabetes
- Dysfunction with
bladder drainage
- Extrinsic compression on ureter
- Ruptured
AAA: edema
-
Retroperitoneal fibrosis
-
Prostate
- Urethral
strictures
Post Renal
Presentation
- Can present with pain or not
- Decreased urine output or outflow
- Hypertensive
- Volume overload
Treatment
- Foley distal obstructions of urethra
- Imaging: ultrasound
- Horizontal view:
- Normal: (bright
white) collecting system is collapsed due to normal drainage of
pelvis
- Post renal
obstruction
- Dilated (dark pools) collecting system
- Chronic obstruction
- Functional dilatation
- Further testing: functional lasix
radiograph
- Kidney transplant: functional dilated
picture
- Changed
physiology of the ureter, and can get flow both ways and thus
chronic dilation
Thanks for listening.